In the case of afatinib and PHA-665752 resistance, upregulation of ABCB1 expression was connected with selection for a cancer stem cell phenotype and an epithelial-to-mesenchymal transition (EMT) switch [41]. resensitized DMS114/NIN cells against nintedanib by downregulation of ABCB1 expression. PKC and downstream NFB were identified as major downstream players in … Continue reading In the case of afatinib and PHA-665752 resistance, upregulation of ABCB1 expression was connected with selection for a cancer stem cell phenotype and an epithelial-to-mesenchymal transition (EMT) switch [41]